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Thus, OPH and NOPH are likely generated by the depletion of cysteine (not GSH per se) caused by its accelerated incorporation into GSH to cope with the increased GSH need for the detoxification of oxidants and glucose-catabolites (methylglyoxal, See below)
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therefore, the decrease in GH in obesity may be caused by altered insulin feedback, rather than being a consequence of elevated plasma FFA levels, although there is no doubt about the effect of FFAs on the pituitary response to GHRH and SS
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