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The glutamatergic system is the leading excitatory network in the brain, and the analyzed interventions focused primarily on modulating its major classes of receptors, including ionotropic N -methyl-D-aspartate receptors (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazolopropionic acid (AMPA), and metabotropic glutamate (mGlu) receptors [49]
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doi: 10.1016/0014-2999(91)90572-8
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