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Heme occurs abundantly in red meat 8 , whose consumption has been classified as possibly carcinogenic to humans by the International Agency for Research on Cancer 9
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Response to Cellular Insults In mammalian cells, IDH activity increases in response to a variety of oxidative insults, but activity of other TCA cycle enzymes, including α-ketoglutarate dehydrogenase and IDH3, decreases (36), suggesting that these enzymes play a role in the cellular response to such insults, in addition to their roles in normal cellular metabolism
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