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Abdominal irradiation induces intestinal epithelial cell apoptosis and that treatment with GH or IGF1 treatment can significantly inhibit this effect (Mylonas et al., 2000), while there is study also suggests that GH shows radioprotective effect through increasing local IGF1 level and counteracting cell apoptosis (Mahran et al., 2015)

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For clinical translation, non-invasive alternatives (e.g., intranasal NSC-derived exosomes, focused ultrasound-enhanced IV delivery) should be prioritized, as pioneered in recent ASD trials using intranasal routes [37, 38]