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Simultaneously, its consumption of SAM methyl groups depletes the methyl pool available for epigenetic and metabolic methylation reactions and creating a dual metabolic drain on two of the most important regulatory systems in cell biology
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[DOI] [PMC free article] [PubMed] [Google Scholar] Gao Y, Shao J, Jiang Z, Chen J, Gu S, Yu S, Zheng K, and Jia L (2014) Drug enterohepatic circulation and disposition: constituents of systems pharmacokinetics
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