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Supplementing nitrate or L-arginine might boost metabolic activity in nutrient-deprived regions, making them more susceptible to tobramycin as well as ciprofloxacin ( 3.4 Reducing penetration or preventing access The structure and makeup of the extracellular matrix (ECM) can significantly impact antibiotic penetration, its entry into cells and ultimately, antibiotic effectiveness through gradients of dispersion (de Beer et al., 1994b)
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But research supporting these claims is still limited compared to what manufacturers often suggest
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