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Effects on frontal or vertex follicles (where hair loss actually occurs) may differ, though subsequent studies have confirmed activity in these regions

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This network includes synthase (ATX, AGK) upregulation and epigenetic dysregulation, dynamic receptor expression profile changes (LPAR1, LPAR3, LPAR6), and sustained activation of multiple downstream signaling pathways (Gα12/13-RhoA-ROCK, PI3K-AKT-mTOR, ERK, NF-κB)