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Indeed, it was recently reported that treatment of cells with H 2 O 2 , which can lower GSH levels, leads to increased expression of NRF2 target genes in a KEAP1-independent mechanism 69
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In its active form, GSK-3 requires its substrate to first be phosphorylated by a “priming” kinase at an amino acid that typically resides four residues to the C-terminal side of the GSK-3 site [295–297]
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