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Thus, it is clear that hypoxia-induced angiogenesis is responsible for an abnormal tumor vasculature (Carmeliet and Jain, Role of hypoxia-induced VEGF in modulating tumor response to cytotoxic T-lymphocytes We have shown that hypoxic exposure of tumor cells inhibits autologous cytotoxic T-lymphocytes (CTL)-mediated lysis (Noman et al., 2009, 2011b)
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