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PGE2 is capable of mediating these effects through a wide variety of signaling pathways, such as the activation of the vascular endothelial growth factor receptor (VEGFR) pathway, which can lead to an increased proliferation, metastatic potential, and angiogenesis of cells and an increased expression of protooncogenes such as BCL-2 [110]
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There are four reasons why we suggest that the diagnosis of MHF and grading of the severity of MHF should be established according to the serum concentrations of ferritin
reliable experience.
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