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however, in 1950, an improved synthesis method was developed by the Maumee Chemical Company (Toledo, OH, United States), which involves diazotization of anthranilic acid to yield saccharin and is currently used in manufacturing ( Aspartame (N-L-α-aspartyl-L-phenylalanine1-methyl ester) is a methyl ester of a dipeptide composed of aspartic acid and L-phenylalanine that was discovered in 1967 ( Acesulfame potassium (6-methyl-1,2,3-oxathiazine-4(3H)-one 2,2-dioxide) is the potassium salt of asulfame, a hydrophilic acidic cyclic sulfonamide that belongs to the oxathiazinonedioxide class ( Sucralose (1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-α-D-galactopyranoside) is structurally similar to sucrose via the replacement of hydroxyl groups with chlorine in the 4, 1′, and 6′ positions ( Neotame N-[N-(3,3-dimethylbutyl)-l- aspartyl]-L-phenylalanine 1-methyl ester) was discovered in the 1980s and is obtained by the reductive alkylation of aspartame, which is converted into 3,3-dimethylbutraldehyde and thus, is structurally similar to aspartame (i.e., N-N-(3,3-dimethylbutyl-L-α-aspartyl-L-phenylalanine-l-methyl ester)

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