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enzyme induction, hepatic disease: affects clearance of drugs with low extraction ratios): Examples -- Social factors : Tobacco smoke induces some hepatic microsomal drug metabolizing enzyme isoforms (CYP1A1, CYP1A2, and possibly CYP2E1) Chronic ethanol use induces CYP2E1 Dietary considerations: Grapefruit juice contains chemicals that are potent inhibitors of CYP3A4 localized in the intestinal wall mucosa Cruciferous vegetables such as brussels sprouts, cabbage, cauliflower and hydrocarbons present in charcoal-broiled meats can induce CYP1A2

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This is consistent with the results of the MD simulations, which showed that the mobilities were 10 4 times higher in the 50% w/w mixture than the neat liquid