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Overall, increased HC levels may be falsely inflating B12 serum levels and could even be depriving tumors and normal tissues of sufficient B12

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However, as the authors stated, a limitation of this study could be the selection of the participants, since the men aged ≥ 75 years with preexisting hypertension were not selected based on high homocysteine levels or low vitamin serum concentrations and this could have compromised the effect size of the intervention [165]