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A completed phase II clinical trial (nct01504854) showed that high-dose resveratrol showed acceptable safety in patients with AD and could significantly reduce the level of Aβ 40 biomarker in cerebrospinal fluid (Moussa et al., 2017), but it failed to translate into significant improvement in cognitive function, which may be related to its relatively low permeability of the blood–brain barrier and complex multi-target characteristics