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The accumulation of α-syn in DA neurons into higher molecular pathological structures causes neurodegeneration, which further affects autophagy/lysosomal balance, mitochondrial homeostasis, ER, synaptic function, oxidative stress, and excitotoxicity [156]
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Since immune function is a systemic measure of general health, a higher IMMUNIDEX™ score is generally desired since it means a person can respond efficiently not only to exogenous threats such as pathogens or allergens, but also to endogenous threats like tumors
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