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They should not be used by individuals with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2)
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In addition, several targeted therapies were approved as rational combinations (e.g., dabrafenib plus trametinib , sotorasib plus panitumumab ), underscoring the growing role of multi-pathway blockade strategies in the management of resistant or advanced malignancies
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