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We found that EPRS1 specifically responds to inflammatory signals mediated by the TLR/PI3K/AKT axis and traffics AKT to early endosomes, where EPRS1 coordinates anti-inflammatory–specific AKT signaling for inflammation resolution
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Male Sprague-Dawley rats (250+ g) were obtained from Harlan Laboratories (CA, USA) and allowed food (Harlan Teklad rodent diet) and water ad libitum in our animal facility
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