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While these medications serve important roles in specific clinical scenarios (assisted reproduction, acne, hirsutism management), they do not fully address the underlying pathophysiology of PMOS, namely hyperinsulinemia, insulin resistance, and chronic low-grade inflammation.[1][2][3] Consequently, they may fall short in preventing long-term complications such as cardiovascular disease and type 2 diabetes.[4][5] Based on current clinical evidence, seven supplements with research supporting their use in PCOS, now called PMOS, are inositol, magnesium, berberine, N-acetyl-cysteine (NAC), fish oil (omega-3), vitamin D, and CoQ10

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10.1021/bi0007674 Biochemistry 121 SunX