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This absence of IGF-1 stimulation is critical for appetite neutrality because IGF-1 has known effects on hypothalamic neuropeptide expression, including alterations to neuropeptide Y (NPY) and agouti-related peptide (AgRP), both potent appetite stimulators
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The "classroom" framing used in the caption suggests a community of paying followers is receiving this information as clinical guidance, which raises additional concerns about how it is being applied
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