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Lysine 258 in aspartate aminotransferase: enforcer of the Circe effect for amino acid substrates and general-base catalyst for the 1,3-prototropic shift

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As shown in Figure 1, at the glomerular level, increased transcapillary pressure and shear stress contribute to endothelial dysfunction, podocyte injury and expansion of the mesangial matrix ( FIGURE 1 Filtered albumin, lipids and glucose are reabsorbed by proximal tubular cells, where they can trigger oxidative stress, endoplasmic reticulum stress and activation of proinflammatory pathways, resulting in the production of chemokines and cytokines such as monocyte chemoattractant protein-1 and interleukin-6 (Zhang et al., 2021)