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While translation proceeds with fully unprotected amino acids under physiological conditions with a speed of 20 amino acids per second, 47 synthetic chemistry usually requires bulky protecting groups, additives, sensitising coupling reagents and excessive volumes of toxic organic solvents to generate peptide chains over many hours if not days

vitamin deficiency.

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Acetylcholine via the vagus nerve can also stimulate some stomach acid release by stimulating M3 (muscarinic acetylcholine) receptors