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Treatment is most biologically plausible when: Greying is recent or patchy Hair thinning accompanies pigment loss Scalp inflammation is present The individual is under 50 (though this is not absolute) In contrast, long-standing white hair often reflects melanocyte depletion rather than dysfunction
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Indeed, neither the in vitro nor the animal studies available can distinguish between primary and secondary mitochondrial and ER dysfunction induced by colistin
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