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Extending this paradigm, GSTP has further been identified as an endoplasmic reticulum (ER)-resident protein that catalyzes S-glutathionylation of critical ER proteins — including PDI, BiP, calnexin, and SERCA — thereby influencing the unfolded protein response (UPR) and linking redox regulation to protein folding homeostasis [68]
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Secondly, the key inflammatory cytokine in OA IL-1β could suppress the expression of GPX4 in chondrocytes [22]
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