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Por eso tiene efecto sobre la cicatrización tendinosa sin cambios endocrinos (hormonales) sistémicos, sin efectos secundarios del tipo acromegalia
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The metabolic effects of metformin vary somewhat across gram-negative bacteria: (1) in E coli metformin inhibits respiratory chain complex I, impairing the function of the inner membrane vitamin B12 transporter (BtuCD), so vitamin B12 entry is blocked at the inner membrane, causing vitamin B12 to accumulate in the periplasm
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