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During alcohol abuse, the demand for ketone bodies in the brain increases, and adaptation to repeated alcohol intake occurs, while acetate levels decline during withdrawal, and supplementation of ketone bodies through a KD may alleviate withdrawal symptoms due to the sudden shift in metabolic status (106)
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PGC-1 binds to peroxisome proliferator-activated receptors (PPARs), which act on dystrophic muscular systems, resulting in a reduced ability of mitochondria to oxidatively phosphorylate, and an increased production of ROS (41)
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