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Finally, FGF21 reduces expression and activation of the NLRP3 inflammasome in vascular endothelial cells in diabetic mice (184), which both protects the cells themselves and reduces further inflammatory damage by suppressing pyroptosis and immune cell recruitment (185)

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Certain gut bacteria can increase heavy metal absorption, while other bacteria can help by demethylating methylmercury, converting it to the inorganic form that is more easily excreted.[ref] We want mercury to be excreted as quickly as possible so that it doesn’t hang around and end up in the brain