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[8] [19] Reference ranges may vary between laboratories Full blood count – may show macrocytic anaemia, though this may be absent in patients with neurological involvement Methylmalonic acid (MMA) and homocysteine – these metabolites accumulate in B12 deficiency and can confirm the diagnosis when serum B12 is borderline
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Surprisingly, CD38 bound to the plasma membrane has its catalytic site located on the extracellular domain of the cell, which poses theoretical difficulties for understanding how CD38 generates cADPR in the cytoplasm, where it should be available to interact with calcium channels
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