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Taken together, the above discussion is consistent with the notion that although further studies are needed to better understand the cross talk between OS and tau phosphorylation/dephosphorylation, a close interplay exists that suggests that these events are key components of a vicious circle that plays a crucial role in tau pathology in AD
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Current scientific research continues to investigate NAD+ metabolism, NAD+ precursors, cellular compartmentalisation, redox biology and the factors that influence NAD+ availability
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