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The pre-symptomatic Tg2576 mice revealing decreased expression of the vitamin B12 transporter cubulin also showed elevated levels of interleukin-9 (IL-9), vascular endothelial growth factor-α (VEGF-α) and interferon-gamma-induced protein 10 kD (IP-10) compared to age-matched littermates and symptomatic Tg2576 mice, indicating that peripheral disturbances in pro-inflammatory and angiogenic plasma cytokines occur prior to the development of cerebral pathology [139]