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Dietary tryptophan is metabolized by the gut microbiota into aryl hydrocarbon receptor agonists such as indoxyl-3-sulfate and indole-3-propionic acid, which can modulate astrocyte inflammatory function trough limiting NF-κB activation in a suppressor of cytokine signalling 2-dependent manner (Rothhammer et al
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85 A randomized controlled trial in 769 infertile men with low sperm numbers and MTHFR polymorphisms found, in those with the MTHFR 677 TT genotype, 800 mcg (1,360 mcg DFE) folic acid daily for three months improved semen parameters and sperm fragmentation
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