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The primary limitations include the relatively short duration of published studies (maximum 26 weeks for the phase 2 monotherapy data), limited long-term safety data, absence of completed cardiovascular outcome trial data, and the fact that phase 3 results are primarily available as conference presentations rather than full publications

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A meaningful share of what users describe as "side effects" actually stems from other ingredients in the serum (preservatives, fragrances, solvents, or high concentrations of exfoliating acids) rather than the copper tripeptide in isolation