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Below are structured mechanisms for key symptoms:- Hot Flashes and Night Sweats: Primary Drivers: Estrogen withdrawal triggers hypothalamic thermoregulatory dysregulation, characterized by TRPV1 (Transient Receptor Potential Vanilloid 1) overactivation and nitric oxide (NO) surge in cutaneous blood vessels

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🔹 Strong Phase 3 results (REDEFINE 1) • ~23% mean weight loss at 68 weeks (on-treatment) • ~92% achieved ≥5% weight loss • ~54% reached a non-obesity BMI ( (1) Strategy reset = “back to Novo DNA”: tighten focus on diabetes + obesity, and enter adjacencies only when anchored to those patient populations (e.g., no “stand-alone CKD push” unless tied to obese/diabetic cohorts)