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While it may be possible that excessive elimination of synapses on otherwise healthy neurons is a driving step towards cell death, it conversely is possible that already injured neurons may signal for phagocytes to remove synapses that may contribute to excessive excitatory signaling that could cause oxidative stress, and recent discussion has questioned whether aberrant synaptic “stripping” is involved in disease pathogenesis 166
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The mRNA is subsequently transported to the rough endoplasmic reticulum (RER) and translated into the pre-procollagen chain [1]
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