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TPS is a secretion pathway that appears to play diverse roles in several Gram-negative bacteria and includes a large secreted protein (generally referred to as TpsA) and a channel-forming β barrel outer membrane activator/transport protein (TpsB) (Henderson et al., 2004

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The author proposed that enhanced PKA activity inhibits cRaf-1 (a proto-oncogene serine/threonine-protein kinase) by phosphorylation at serine259, decreasing nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) activity and the expression of NFκB-controlled genes such as BACE1 in the hippocampus of treated AD Tg mice (Arendash et al., Swe mice (Zeitlin et al., 2011)