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Studies in the field of accelerated aging have established a link between PARP activation and impaired mitochondrial health, which is associated with reduced NAD + levels resulting from PARP hyperactivation 158
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Merck KGaA, Darmstadt, Germany), MS settings of the screening method used in 2020–2023 were switched to high-mass detection (m/z 700–3,000) and the ESI-L LCMS Tuning Solution (Agilent Technologies) was used for calibration, whereas, in the screening method used in 2024 the data acquisition range was changed to m/z 100–3,000, and a sodium iodide solution was used for MS calibration
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