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Disruption of the BBB including compromised BBB integrity and subsequent leakage of plasma constituents into the brain parenchyma, and impaired BBB dysfunction consisting of compromised transport system, reduced CBF, and heightened vascular inflammatory response at the BBB level, which are closely interlinked with the accumulation of AΞ² and the presence of neurofibrillary tangles [137]
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The University of Arizona research team that developed it reported cognitive rescue in animal models of Alzheimer's disease
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