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Discussion Our structural and functional analyses reveal that binding of one IGF1 molecule to IGF1R disrupts the Λ-shaped autoinhibited IGF1R dimer and triggers a conformational rearrangement that leads to the formation of an asymmetric Γ-shaped active dimer (Fig
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[DOI] [PubMed] [Google Scholar] 187.Mazurier J, Legrand D, Hu WL, Montreuil J, Spik G
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