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Glucose-6-phosphate dehydrogenase (G6PD) deficiency is linked with cardiovascular disease | Hypertension Research

however, in 1950, an improved synthesis method was developed by the Maumee Chemical Company (Toledo, OH, United States), which involves diazotization of anthranilic acid to yield saccharin and is currently used in manufacturing ( Aspartame (N-L-α-aspartyl-L-phenylalanine1-methyl ester) is a methyl ester of a dipeptide composed of aspartic acid and L-phenylalanine that was discovered in 1967 ( Acesulfame potassium (6-methyl-1,2,3-oxathiazine-4(3H)-one 2,2-dioxide) is the potassium salt of asulfame, a hydrophilic acidic cyclic sulfonamide that belongs to the oxathiazinonedioxide class ( Sucralose (1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-α-D-galactopyranoside) is structurally similar to sucrose via the replacement of hydroxyl groups with chlorine in the 4, 1′, and 6′ positions ( Neotame N-[N-(3,3-dimethylbutyl)-l- aspartyl]-L-phenylalanine 1-methyl ester) was discovered in the 1980s and is obtained by the reductive alkylation of aspartame, which is converted into 3,3-dimethylbutraldehyde and thus, is structurally similar to aspartame (i.e., N-N-(3,3-dimethylbutyl-L-α-aspartyl-L-phenylalanine-l-methyl ester)

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