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Older dogs exhibit neurocognitive behavioral changes that are attributed to increased oxidative damage in the brain, suggesting that oxidative stress plays a role in brain aging and cognitive decline [78,79]
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Moreover, Aβ 1–16 contains most of the reaction sites of the Aβ protein that could be involved in the ACR-mediated carbonylation process (N-terminal amino group, His, Lys and Arg)
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