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The Aib residue at position 2 and the fatty acid modification both confer resistance to the primary degradation enzymes (DPP-4 and neprilysin), extending the metabolic half-life

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Based on the patient population we see in Doral, the strongest candidates typically include: Patients with chronic or multi-site injuries: TB-500’s systemic distribution makes it particularly relevant for patients with injuries across more than one joint or tissue type, where localized injection alone would require multiple sites per session