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Under the ICD-10-CM Official Guidelines for Coding and Reporting (FY2026), neoplasms are classified into four behavioral categories: Malignant — invasive, capable of metastasis (C00–C96, C7A, C7B) In situ — confined to epithelium without invasion (D00–D09) Benign — non-invasive (D10–D36) Uncertain/Unspecified behavior — D37–D48 / D49 For clinical documentation and coding purposes, the three status distinctions that drive code selection, sequencing, and HCC risk adjustment are: Active malignancy — cancer currently present or under active treatment