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However, research into "reversible graying" has shown that in some cases, particularly when graying is triggered by a sudden period of intense stress or a specific nutritional deficiency, the process may be partially reversible

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In vivo, GPx1 −/− mice had a deficiency of progenitor cells as they failed to increase progenitor cell number following subcutaneous injection of vascular endothelial growth factor or in response to ischemic injury in the hindlimb ischemia model