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A 2022 network meta-analysis in World Psychiatry pooled 92 randomized trials and 22,645 participants and found that LAIs hold up against daily oral antipsychotics in preventing relapse (Ostuzzi et al., 2022)
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This is the Perfect B supervised convention rather than a validated pharmacologic requirement: there is no evidence of pituitary downregulation on this timescale, and the pause is a conservative choice given the absence of long term human safety data
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